What is Neutron Therapy?
Neutron therapy is a highly effective form of radiation therapy. Long-term experience with treating cancer has shown that certain tumor types (pathologies) are very difficult to kill using conventional radiation therapy. These pathologies are classified as being "radioresistant." Neutron therapy specializes in treating inoperable, radioresistant tumors occurring anywhere in the body.
Radiation therapy is the use of penetrating beams of ionizing radiation, primarily to treat cancerous/malignant tumors. Conventional radiation therapy includes photon (x-ray) and electron radiation, which is available at many clinics and hospitals. These beams are produced by electron accelerators or from radioactive sources such as cobalt. Hadron therapy includes neutrons and protons, which are generated using proton or deuteron accelerators.
The basic effect of ionizing radiation is to destroy the ability of cells to divide, by damaging their DNA strands. For photon, electron and proton radiation the damage is done primarily by activated radicals produced from atomic interactions. These types of radiation are called low linear-energy-transfer (low LET) radiation. Neutrons are high linear-energy-transfer (high LET) radiation and the damage is done primarily by nuclear interactions. If a tumor cell is damaged by low LET radiation it has a good chance to repair itself and continue to grow. With high LET radiation the chance for a damaged tumor cell to repair itself is very small.
In general, fast neutrons can control very large tumors, because unlike low LET radiation, neutrons do not depend on the presence of oxygen to kill the cancer cells. In addition, the biological effectiveness of neutrons is not affected by the time or stage in the life cycle of cancer cells, as it is with low LET radiation. It often happens that large tumors have metastasized (spread) to other parts of the body before the patient seeks treatment. In these cases neutrons can be used to control the primary tumor, but chemotherapy must be used to limit the spread of cancer through the rest of the body.
Because the biological effectiveness of neutrons is so high, the required tumor dose to kill cancer cells is about one-third the dose required with photons, electrons or protons. A full course of neutron therapy is delivered in only 10 to 12 treatments, compared to 30 - 40 treatments needed for low LET radiation. Neutron radiotherapy is offered at the Northern Illinois University Institute for Neutron Therapy at Fermilab (NIUINT at Fermilab). Physicians staffing the clinic are members of the Nuclear Oncology Service Corporation, which was founded by Dr. Frank Hendrickson. Other medical staff members are employees of Northern Illinois University and Fermilab.
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